NF-kB

Molecular immunology

(NF-kB, Interferons, nucleic acids senSors)

 

summary:  NF-κB is a master regulator of inflammation, implicated in the pathogenesis of immune disorders and cancer. Interferons are key antiviral factors. Cytoplasmic PRRs are sensors of both infections and cellular damages. All these factors are orchestrating responses toward constant challenges from inside and outside of our body. Mutations or ageing may disorganize these and dozen other regulators that may lead to development of the immune and autoimmune diseases. The main goal of my projects is to reveal the molecular mechanisms of immune diseases to define therapeutic targets.

       

LOCATIONS:

2010-present - UT Southwestern Medical Center, Dallas, TX (NF-kB, IFNa/b, and DNA-sensing pathways)

2007-2010  - Weizmann Institute of Science, Rehovot, Israel (NF-kB pathway)

 

Publications:

Published:

1. Starokadomskyy P, et al. DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis //Nature Immunology. 17:495-504. 2016. PMID: 27019227

2. Starokadomskyy P, et al. CCDC22 deficiency in humans blunts activation of pro-inflammatory NF-κB signaling //J Clin Invest. 1;123(5):2244-56. 2013. PMID: 23563313

3. Mao X, Gluck N, Chen B, Starokadomskyy P, Li H, Maine GN, Burstein E. COMMD1 regulates Cullin-RING ligases by preventing CAND1 binding // Journal of Biological Chemistry, 286: 32355-32365; 2011. PMID: 21778237

4. Li H, Chan L, Bartuzi P, Melton SD, Mao X, Starokadomskyy P, Ben-Shlomo S, Sharvit E, Sommeren S, Mokadem M, Weisberg R, Westra H, Esko T, Mespalu A, Genta RM, Yarovinsky F, Hofker M, Wijmenga C, Franke L, Aguirre V, Weersma R, Gluck N, van de Sluis B, Burstein E. COMMD1 restrains pro-inflammatory gene expression and protects from colitis and cancer progression // Gastroenterology, 147(1):184-195; 2014. PMID: 24727021

5. Phillips-Krawczak CA, Singla A, Starokadomskyy P, Deng Z, Osborne DG, Li H, Dick CJ, Gomez TS, Koenecke M, Zhang JS, Dai H, Sifuentes-Dominguez LF, Geng LN, Kaufmann SH, Hein MY, Wallis M, McGaughran J, Gecz J, Sluis B, Billadeau DD, Burstein E. COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A // Mol Biol Cell, 26(1):91-103; 2015. PMID: 25355947

 

Book chapters:

1. Starokadomskyy P, Burstein E. Bimolecular affinity purification - a variation of TAP with multiple applications // Method in Molecular Biology (Protein Affinity Tags), 2014. PMID: 24943324

2. Starokadomskyy P, Burstein E. Detection of IkB degradation dynamics and IkB-a ubiquitination // Method in Molecular Biology (Protein Affinity Tags), 2015. PMID: 25736741

3. Li H., Starokadomskyy P, Burstein E. Methodology to study NF-kB/RelA ubiquitination in vivo // Method in Molecular Biology (Protein Affinity Tags), 2015. PMID: 25736761

 

HIGHLIGHTS and awards:

A human inborn error connects the α's. Nature News and Views

Researchers find mutation that causes rare disease and confirm a role for nucleic acids in immune function. UTSW News

 

 

 

 

 

 

 

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